Unterschiede

Hier werden die Unterschiede zwischen zwei Versionen angezeigt.

--- krankheiten:encephalitozoonose [2026/01/25 17:59] – [Widerstandsfähigkeit der Sporen] kathrin
+++ krankheiten:encephalitozoonose [2026/01/25 19:09] (aktuell) – [Etablierung von Richtlinien zur Diagnose und Behandlung] kathrin
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 Jeklova //et al//., 2020((Jeklova, E., Leva, L., Matiasovic, J., Ondrackova, P., Kummer, V., & Faldyna, M. 2020. Characterization of humoral and cell-mediated immunity in rabbits orally infected with Encephalitozoon cuniculi. Veterinary research, 51(1), 79.)) simulierten den natürlichen Infektionsweg indem sie immunkompetente SPF-Kaninchen experimentell oral infizierten (Versuchsgruppe, n=20; Kontrollgruppe, n=5). Folglich beschrieben sie detailliert die Ausbreitung von //E. cuniculi// im Organismus sowie die humorale und zelluläre Immunantwort, einschließlich Zytokinproduktion, über einen Zeitraum von 8 Wochen.\\
-Schlussfolgerung: //"Based on the present results, we can conclude that oral E. cuniculi infection in immunocompetent rabbits caused subclinical infection with the activation of humoral and cell-mediated immune responses. Dissemination of microsporidia in the body of the rabbit, especially to nervous tissue, is more rapid than previously reported, as E. cuniculi was detected in various nervous tissue as early as 2 weeks pi. Cell-mediated immunity was characterized by ability of both CD4+ and CD8+ T cells to proliferate after stimulation with specific antigens. Th1 polarization of immune response with a predominance of IFN-γ expression was detected in spleen, mesenteric lymph nodes and Peyer’s patches. The increased expression of IL-4 and IL-10 mRNA in mixed samples from the small intestine is indicative of balanced control of IFN-γ, which prevents tissue damage. On the other hand, it can play role in ability of E. cuniculi to survive and persist in the host organism in a balanced host-parasite relationship. The Th17 immunity lineage seems to play only a minor role in rabbit encephalitozoonosis."//
+Schlussfolgerung: //"Based on the present results, we can conclude that oral E. cuniculi infection in immunocompetent rabbits caused subclinical infection with the activation of humoral and cell-mediated immune responses. Dissemination of microsporidia in the body of the rabbit, especially to nervous tissue, is more rapid than previously reported, as E. cuniculi was detected in various nervous tissue as early as 2 weeks pi. Cell-mediated immunity was characterized by ability of both CD4+ and CD8+ T cells to proliferate after stimulation with specific antigens. Th1 polarization of immune response with a predominance of IFN-γ expression was detected in spleen, mesenteric lymph nodes and Peyer’s patches. The increased expression of IL-4 and IL-10 mRNA in mixed samples from the small intestine is indicative of balanced control of IFN-γ, which prevents tissue damage. On the other hand, it can play role in ability of E. cuniculi to survive and persist in the host organism in a balanced host-parasite relationship. The Th17 immunity lineage seems to play only a minor role in rabbit encephalitozoonosis."// (Siehe auch „Figure 5.“ in Keeble //et al//., 2026((Keeble, E., Kϋnzel, F., Montiani-Ferreira, F., Graham, J., Jeklová, E., Kanfer, S., Lennox, A., Desoubeaux, G., Biswell, E., Cray, C., & Joachim, A. (2026). Encephalitozoonosis in Pet Rabbits: Epidemiology, Pathogenesis, Immunology and Consensus on Clinical Management. Animals, 16(2), 346. https://doi.org/10.3390/ani16020346)))
+Veränderungen auf Proteinebene wurden von Desoubeaux //et al//., 2017((Desoubeaux, G., Piqueras, M. D. C., Pantin, A., Bhattacharya, S. K., Peschke, R., Joachim, A., & Cray, C. (2017). Application of mass spectrometry to elucidate the pathophysiology of Encephalitozoon cuniculi infection in rabbits. PLoS One, 12(7), e0177961.)) und Duangurai //et al//., 2025((Duangurai, T., Reamtong, O., Thiangtrongjit, T., Jala, S., Chienwichai, P., & Thengchaisri, N. 2025. Serum Proteomic Changes in Pet Rabbits with Subclinical and Clinical Encephalitozoonosis in Thailand. Animals, 15(13), 1962.)) beschrieben.
@@ Zeile 241: / Zeile 242: @@
 Bei neurologischen Symptomen, das Periphere Nervensystem betreffend:
-  * bakterielle [[ohrerkrankungen#otitis|Otitis]] interna/externa,
+  * bakterielle [[ohrerkrankungen#otitis|Otitis]] interna/externa (wichtigste Differenzialdiagnose bei Gleichgewichtsstörungen),
   * traumatische Ruptur (Riss) der Paukenhöhle,
   * Aminoglykosid-vermittelte Ototoxizität (Schädigung von Innenohr oder Hörnerv),
@@ Zeile 561: / Zeile 562: @@
 [[krankheiten:encephalitozoonose#Diagnostik|Diagnose]] und [[krankheiten:encephalitozoonose#Therapie|Behandlung]] einer Mikrosporidiose sind mit gewissen Herausforderungen verbunden, die durch standardisierte Vorgehensweisen reduziert werden könnten.((Vergneau-Grosset, C., & Larrat, S. 2015. Microsporidiosis in vertebrate companion exotic animals. Journal of Fungi, 2(1), 3.))((Montiani-Ferreira, F., Joachim, A., Künzel, F., Mello, F. R., Keeble, E., Graham, J., ... & Cray, C. 2024. Encephalitozoon cuniculi Infection in Rabbits (Oryctolagus cuniculus): Data from an International Survey of Exotic and Small Animal Veterinarians. Animals, 14(22), 3295.))((Doboși, A. A., Paștiu, A. I., Andrei, S., & Pusta, D. L. 2025. Comparative Evaluation of the Serological Methods and the Molecular Genetics Techniques for the Diagnosis of Encephalitozoon cuniculi in Rabbits (Oryctolagus cuniculus). Microorganisms, 13(7), 1478.))
-<note tip>Keeble //et al//., 2026((Keeble, E., Kϋnzel, F., Montiani-Ferreira, F., Graham, J., Jeklová, E., Kanfer, S., Lennox, A., Desoubeaux, G., Biswell, E., Cray, C., & Joachim, A. (2026). Encephalitozoonosis in Pet Rabbits: Epidemiology, Pathogenesis, Immunology and Consensus on Clinical Management. Animals, 16(2), 346. https://doi.org/10.3390/ani16020346)) -- Überblick über Biologie und klinische Erscheinungsformen der Erkrankung Enzephalitozoonose sowie aktueller Konsens über die Verwendung von Diagnostik und Behandlungsschemata</note>
+<note tip>Keeble //et al//., 2026((Keeble, E., Kϋnzel, F., Montiani-Ferreira, F., Graham, J., Jeklová, E., Kanfer, S., Lennox, A., Desoubeaux, G., Biswell, E., Cray, C., & Joachim, A. (2026). Encephalitozoonosis in Pet Rabbits: Epidemiology, Pathogenesis, Immunology and Consensus on Clinical Management. Animals, 16(2), 346. https://doi.org/10.3390/ani16020346)) -- Überblick über Biologie und klinische Erscheinungsformen der Erkrankung Enzephalitozoonose sowie aktueller Konsens über die Verwendung von Diagnostik und Behandlungsschemata; außerdem Vorschläge für zukünftige Forschungsschwerpunkte</note>
+Zur Eindämmung der Ausbreitung von //E. cuniculi// in der Kaninchenpopulation wurde vorgeschlagen, Tiere vor ihrer Verwendung zur Zucht auf Antikörper testen zu lassen und seropositive Tiere von der Zucht auszuschließen.((Keeble, E., Kϋnzel, F., Montiani-Ferreira, F., Graham, J., Jeklová, E., Kanfer, S., Lennox, A., Desoubeaux, G., Biswell, E., Cray, C., & Joachim, A. (2026). Encephalitozoonosis in Pet Rabbits: Epidemiology, Pathogenesis, Immunology and Consensus on Clinical Management. Animals, 16(2), 346. https://doi.org/10.3390/ani16020346))
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